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Article

Acute inhibition of myoglobin impairs contractility and energy state of iNOS-overexpressing hearts.

Circulation research - 27 Jun 2003

Wunderlich Carsten, Flögel Ulrich, Gödecke Axel, Heger Jacqueline, Schrader Jürgen

Abstract excerpt

Elevated cardiac levels of nitric oxide (NO) generated by inducible nitric oxide synthase (iNOS) have been implicated in the development of heart failure. The surprisingly benign phenotype of recently generated mice with cardiac-specific iNOS overexpression (TGiNOS) provided the rationale to investigate whether NO scavenging by oxymyoglobin (MbO2) yielding nitrate and metmyoglobin (metMb) is involved in...

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Identifiers

PMID: 12775582
DOI: 10.1161/01.RES.0000079026.70629.E5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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