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Article

Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts and iNOS/CBS double knockout mice.

Journal of cellular biochemistry - 1 Jan 2009

Kundu Soumi, Kumar Munish, Sen Utpal, Mishra Paras K, Tyagi Neetu, Metreveli Naira, Lominadze David, Rodriguez Walter, Tyagi Suresh C

Abstract excerpt

Increased levels of homocysteine (Hcy), recognized as hyperhomocysteinemia (HHcy), were associated with cardiovascular diseases. There was controversy regarding the detrimental versus cardio protective role of inducible nitric oxide synthase (iNOS) in ischemic heart disease. The aim of this study was to test the hypothesis that the Hcy generated nitrotyrosine by inducing the endothelial nitric oxide synthase,...

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Source

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Identifiers

PMID: 19021146
DOI: 10.1002/jcb.21982
PMCID: PMC2668975

Genes

CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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