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Article

Disruption of inducible nitric oxide synthase improves beta-adrenergic inotropic responsiveness but not the survival of mice with cytokine-induced cardiomyopathy.

Circulation research - 17 May 2002

Funakoshi Hajime, Kubota Toru, Kawamura Natsumi, Machida Yoji, Feldman Arthur M, Tsutsui Hiroyuki, Shimokawa Hiroaki, Takeshita Akira

Abstract excerpt

Transgenic (TG) mice with cardiac-specific overexpression of tumor necrosis factor-alpha develop congestive heart failure. We have previously reported that short-term inhibition of inducible nitric oxide synthase (iNOS) ameliorates beta-adrenergic hyporesponsiveness in TG mice. To examine whether...

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Identifiers

PMID: 12016261
DOI: 10.1161/01.res.0000017632.83720.68

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12016261-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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