Article
p53 sequence analysis predicts treatment response and outcome of patients with esophageal carcinoma.
Cancer - 1 Jul 1998
Ribeiro U, Finkelstein S D, Safatle-Ribeiro A V, Landreneau R J, Clarke M R, Bakker A, Swalsky P A, Gooding W E, Posner M C
Abstract excerpt
BACKGROUND: The ability to predict biologic behavior and treatment responsiveness would be a valuable asset in the multimodality approach to esophageal carcinoma. The authors examined whether alterations of the p53 gene correlate with clinicopathologic parameters, response to preoperative chemotherapy/radiotherapy, and outcome in patients with esophageal carcinoma. METHODS. Histopathologic/genetic analysis of p53...
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