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Article

A small conserved surface in SUMO is the critical structural determinant of its transcriptional inhibitory properties.

Molecular and cellular biology - 1 May 2005

Chupreta Sergey, Holmstrom Sam, Subramanian Lalitha, Iñiguez-Lluhí Jorge A

Abstract excerpt

Small ubiquitin-like modifier (SUMO) modification of sequence-specific transcription factors has profound regulatory consequences. By providing an intrinsic inhibitory function, SUMO isoforms can suppress transcriptional activation, particularly at promoters harboring multiple response elements. Through a comprehensive structure-function analysis, we have identified a single critical sector along the second beta...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15870296
DOI: 10.1128/MCB.25.10.4272-4282.2005
PMCID: PMC1087732

Genes

SUMO2
SUMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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