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Article

Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.

The Journal of biological chemistry - 18 Mar 2005

Chang Che-Chang, Lin Ding-Yen, Fang Hsin-I, Chen Ruey-Hwa, Shih Hsiu-Ming

Abstract excerpt

Daxx has been shown to function as an apoptosis regulator and transcriptional repressor via its interaction with various cytoplasmic and nuclear proteins. Here, we showed that Daxx interacts with Smad4 and represses its transcriptional activity via the C-terminal domain of Daxx. In vitro and in vivo interaction studies indicated that the binding of Smad4 to Daxx depends on Smad4 sumoylation. Substitution of Smad4...

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Identifiers

PMID: 15637079
DOI: 10.1074/jbc.M409161200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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