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Article

PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions.

Oncogene - 29 Nov 2007

Zhao L-J, Subramanian T, Vijayalingam S, Chinnadurai G

Abstract excerpt

C-terminal binding proteins (CtBPs) are cellular corepressors that are targeted by adenovirus E1A. A conserved motif of E1A (PLDLS) interacts with an N-terminal hydrophobic cleft of CtBPs. Many cellular cofactors also interact with CtBPs through PLDLS-like motifs. E1A interaction with CtBP2 changed the composition of the CtBP2 protein complex and enhanced CtBP2 acetylation. We have identified a mutant of CtBP2...

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Identifiers

PMID: 17546044
DOI: 10.1038/sj.onc.1210569
PMCID: PMC2928068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions.PMID 17546044Read ↗

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