Article
Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1.
Biochemical and biophysical research communications - 5 Mar 2020
Ma Yang, Sekiya Motohiro, Kainoh Kenta, Matsuda Takaaki, Iwasaki Hitoshi, Osaki Yoshinori, Sugano Yoko, Suzuki Hiroaki, Takeuchi Yoshinori, Miyamoto Takafumi, Yahagi Naoya, Nakagawa Yoshimi, Matsuzaka Takashi, Shimano Hitoshi
Abstract excerpt
The epithelial to mesenchymal transition (EMT) is a cell intrinsic program controlling cellular morphological and phenotypic remodeling in a wide range of biological processes. Despite the accumulating evidence, the transcriptional networks regulating EMT still remain to be elucidated. In this study, we demonstrate that C-terminal binding protein 2 (CtBP2), a critical transcriptional co-repressor harboring...
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