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Article

SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis.

Scientific reports - 13 Apr 2017

Rocca Daniel L, Wilkinson Kevin A, Henley Jeremy M

Abstract excerpt

Forkhead Box P (FOXP) transcriptional repressors play a major role in brain development and their dysfunction leads to human cognitive disorders. However, little is known about how the activity of these proteins is regulated. Here, we show that FOXP1 SUMOylation at lysine 670 is required for recruiting the co-repressor CtBP1 and transcriptional repression. FOXP1 SUMOylation is tightly controlled by neuronal...

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Source

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Identifiers

PMID: 28408745
DOI: 10.1038/s41598-017-00707-6
PMCID: PMC5429823

Genes

FOXP1

Variants

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