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Article

Sumoylation controls the timing of Tup1-mediated transcriptional deactivation.

Nature communications - 13 Mar 2015

Ng Chong Han, Akhter Akhi, Yurko Nathan, Burgener Justin M, Rosonina Emanuel, Manley James L

Abstract excerpt

The small ubiquitin-like modifier (SUMO) is implicated in various cellular activities, including transcriptional regulation. We previously showed that the yeast activator Gcn4 becomes sumoylated during activation, facilitating its eventual promoter eviction and transcriptional shut off. Here we show that the corepressor Tup1 is sumoylated, at two specific lysines, under various stress conditions. Mutation of...

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Identifiers

PMID: 25766875
DOI: 10.1038/ncomms7610
PMCID: PMC4360881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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