Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced D-amino acid incorporation into protein by modified ribosomes.

Journal of the American Chemical Society - 4 Jun 2003

Dedkova Larisa M, Fahmi Nour Eddine, Golovine Serguei Y, Hecht Sidney M

Abstract excerpt

By overexpression of modified Escherichia coli 23S rRNAs from multicopy plasmids, ribosomes were prepared that contained mutations in two regions (2447-2450 and 2457-2462) of 23S rRNA. Following mutagenesis and selection, two clones with mutations in the 2447-2450 region (peptidyltransferase center) and six with mutations in the 2457-2462 region (helix 89) were characterized. The mutations were shown to exhibit a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Cell-Free System
Share to Luciferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ribosomes

Share to RNA, Ribosomal, 23S

Share to RNA, Transfer, Amino Acyl

Share to RNA, Transfer, Met

Share to Tetrahydrofolate Dehydrogenase

Source

Identifiers

PMID: 12769555
DOI: 10.1021/ja035141q

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced D-amino acid incorporation into protein by modified ribosomes.PMID 12769555Read ↗

In Vivo Biosynthesis of a β-Amino Acid-Containing Protein.Semantic proximity Read ↗

Mutagenesis of the peptidyltransferase center of 23S rRNA: the invariant U2449 is dispensable.Semantic proximity Read ↗

Generation of ribosomal protein S1 mutants for improving of expression of difficult to translate mRNAs.Semantic proximity Read ↗

Engineered rRNA enhances the efficiency of selenocysteine incorporation during translation.Semantic proximity Read ↗

Function of the ribosomal E-site: a mutagenesis study.Semantic proximity Read ↗

Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit.Semantic proximity Read ↗

Expanding the genetic code of Escherichia coli.Semantic proximity Read ↗

An expanded genetic code in mammalian cells with a functional quadruplet codon.Semantic proximity Read ↗

Non-stressful death of 23S rRNA mutant G2061C defective in puromycin reaction.Semantic proximity Read ↗

Engineering of tRNAPro1E2 anticodon stem enhances multiple/consecutive ribosomal incorporation of N-methyl-l-α-amino acids and d-α-amino acids.Semantic proximity Read ↗

Ribosomes containing mutants of L4 ribosomal protein from Thermus thermophilus display multiple defects in ribosomal functions and sensitivity against erythromycin.Semantic proximity Read ↗

Alterations in ribosomal protein L19 that decrease the fidelity of translation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.