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Article

Generation of ribosomal protein S1 mutants for improving of expression of difficult to translate mRNAs.

Applied microbiology and biotechnology - 23 Jan 2025

Niemelä Laura R K, Pásztor András, Frey Alexander D

Abstract excerpt

Metagenomes present a source for novel enzymes, but under 1% of environmental microbes are cultivatable. Because of its useful properties, Escherichia coli has been used as a host organism in functional genomic screens. However, due to differing expression machineries in the expression host compared to the source organism of the DNA sequences, screening outcomes can be biased. Here, we focused on one of the...

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PMID: 39847144
DOI: 10.1007/s00253-025-13406-4
PMCID: PMC11759276

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