Article
Mutagenesis of the peptidyltransferase center of 23S rRNA: the invariant U2449 is dispensable.
Nucleic acids research - 1 Feb 2001
O'Connor M, Lee W M, Mankad A, Squires C L, Dahlberg A E
Abstract excerpt
U2449 is one of many invariant residues in the central loop of domain V of 23S rRNA, a region that constitutes part of the peptidyltransferase center of the ribosome. In Escherichia coli, this U is post-transcriptionally modified to dihydrouridine (D) and is the only D modification found in E.coli rRNAs. To analyze the role of this base and its modification in ribosomal function, all three base substitutions were...
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