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Article

Non-stressful death of 23S rRNA mutant G2061C defective in puromycin reaction.

Journal of molecular biology - 9 Mar 2012

Sergiev Petr V, Lesnyak Dmitry V, Burakovsky Dmitry E, Svetlov Maxim, Kolb Vyacheslav A, Serebryakova Marina V, Demina Irina A, Govorun Vadim M, Dontsova Olga A, Bogdanov Alexey A

Abstract excerpt

Catalysis of peptide bond formation in the peptidyl transferase center is a major enzymatic activity of the ribosome. Mutations limiting peptidyl transferase activity are mostly lethal. However, cellular processes triggered by peptidyl transferase deficiency in the bacterial cell are largely unknown. Here we report a study of the lethal G2061C mutant of Escherichia coli 23S ribosomal RNA (rRNA). The G2061C...

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PMID: 22245576
DOI: 10.1016/j.jmb.2012.01.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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