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Article

An expanded genetic code in mammalian cells with a functional quadruplet codon.

ACS chemical biology - 19 Jul 2013

Niu Wei, Schultz Peter G, Guo Jiantao

Abstract excerpt

We have utilized in vitro evolution to identify tRNA variants with significantly enhanced activity for the incorporation of unnatural amino acids into proteins in response to a quadruplet codon in both bacterial and mammalian cells. This approach will facilitate the creation of an optimized and standardized system for the genetic incorporation of unnatural amino acids using quadruplet codons, which will allow the...

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Identifiers

PMID: 23662731
DOI: 10.1021/cb4001662
PMCID: PMC4501474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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