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Article

Function of the ribosomal E-site: a mutagenesis study.

Nucleic acids research - 1 Jan 2005

Sergiev Petr V, Lesnyak Dmitry V, Kiparisov Sergey V, Burakovsky Dmitry E, Leonov Andrei A, Bogdanov Alexey A, Brimacombe Richard, Dontsova Olga A

Abstract excerpt

Ribosomes synthesize proteins according to the information encoded in mRNA. During this process, both the incoming amino acid and the nascent peptide are bound to tRNA molecules. Three binding sites for tRNA in the ribosome are known: the A-site for aminoacyl-tRNA, the P-site for peptidyl-tRNA and the E-site for the deacylated tRNA leaving the ribosome. Here, we present a study of Escherichia coli ribosomes with...

Read the complete abstract on PubMed

Topics

Binding Sites
Codon, Terminator
Escherichia coli
Frameshifting, Ribosomal
Mutagenesis
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Peptide Chain Elongation, Translational

Peptide Elongation Factor G

RNA, Ribosomal, 23S

RNA, Transfer

Ribosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 16243787
DOI: 10.1093/nar/gki910
PMCID: PMC1266066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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