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Article

In Vivo Biosynthesis of a β-Amino Acid-Containing Protein.

Journal of the American Chemical Society - 27 Apr 2016

Melo Czekster Clarissa, Robertson Wesley E, Walker Allison S, Söll Dieter, Schepartz Alanna

Abstract excerpt

It has recently been reported that ribosomes from erythromycin-resistant Escherichia coli strains, when isolated in S30 extracts and incubated with chemically mis-acylated tRNA, can incorporate certain β-amino acids into full length DHFR in vitro. Here we report that wild-type E. coli EF-Tu and phenylalanyl-tRNA synthetase collaborate with these mutant ribosomes and others to incorporate β(3)-Phe analogs into...

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Source

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Identifiers

PMID: 27086674
DOI: 10.1021/jacs.6b01023
PMCID: PMC6640638

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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