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Article

Modulation of the rate of cardiac muscle contraction by troponin C constructs with various calcium binding affinities.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2007

Norman Catalina, Rall Jack A, Tikunova Svetlana B, Davis Jonathan P

Abstract excerpt

We investigated whether changing thin filament Ca(2+) sensitivity alters the rate of contraction, either during normal cross-bridge cycling or when cross-bridge cycling is increased by inorganic phosphate (P(i)). We increased or decreased Ca(2+) sensitivity of force production by incorporating into rat skinned cardiac trabeculae the troponin C (TnC) mutants V44QTnC(F27W) and F20QTnC(F27W). The rate of isometric...

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Identifiers

PMID: 17693547
DOI: 10.1152/ajpheart.00039.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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