Article
Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.
Science (New York, N.Y.) - 23 May 2003
Crackower Michael A, Kolas Nadine K, Noguchi Junko, Sarao Renu, Kikuchi Kazuhiro, Kaneko Hiroyuki, Kobayashi Eiji, Kawai Yasuhiro, Kozieradzki Ivona, Landers Rushin, Mo Rong, Hui Chi-Chung, Nieves Edward, Cohen Paula E, Osborne Lucy R, Wada Teiji, Kunieda Tetsuo, Moens Peter B, Penninger Josef M
Abstract excerpt
Meiosis is a critical stage of gametogenesis in which alignment and synapsis of chromosomal pairs occur, allowing for the recombination of maternal and paternal genomes. Here we show that FK506 binding protein (Fkbp6) localizes to meiotic chromosome cores and regions of homologous chromosome synapsis. Targeted inactivation of Fkbp6 in mice results in aspermic males and the absence of normal pachytene...
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