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Article

Regulating chromosomal movement by the cochaperone FKB-6 ensures timely pairing and synapsis.

The Journal of cell biology - 1 Feb 2017

Alleva Benjamin, Balukoff Nathan, Peiper Amy, Smolikove Sarit

Abstract excerpt

In meiotic prophase I, homologous chromosome pairing is promoted through chromosome movement mediated by nuclear envelope proteins, microtubules, and dynein. After proper homologue pairing has been established, the synaptonemal complex (SC) assembles along the paired homologues, stabilizing their interaction and allowing for crossing over to occur. Previous studies have shown that perturbing chromosome movement...

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Identifiers

PMID: 28077446
DOI: 10.1083/jcb.201606126
PMCID: PMC5294783

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