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Article

Is a genetic defect in Fkbp6 a common cause of azoospermia in humans?

Cellular & molecular biology letters - 1 Jan 2006

Miyamato Toshinobu, Sato Hisashi, Yogev Leah, Kleiman Sandra, Namiki Mikio, Koh Eitetsu, Sakugawa Naoko, Hayashi Hiroaki, Ishikawa Mutsuo, Lamb Dolores J, Sengoku Kazuo

Abstract excerpt

FK506-binding protein 6 (Fkbp6) is a member of a gene family containing a prolyl isomerase/FK506-binding domain and tetratricopeptide protein-protein interaction domains. Recently, the targeted inactivation of Fkbp6 in mice has been observed to result in aspermic males and the absence of normal pachytene spermatocytes. The loss of Fkbp6 results in abnormal pairing and a misalignment of the homologous chromosomes,...

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Identifiers

PMID: 16983454
DOI: 10.2478/s11658-006-0043-1
PMCID: PMC6275806

Genes

FKBP6

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Is a genetic defect in Fkbp6 a common cause of azoospermia in humans?PMID 16983454Read ↗

Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia.Semantic proximity Read ↗

Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.Semantic proximity Read ↗

A novel mutation in FK506 binding protein-like (FKBPL) causes male infertility.Semantic proximity Read ↗

[Possible association between 278C/A single nucleotide polymorphism of FKBP6 and idiopathic azoospermia].Semantic proximity Read ↗

Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.Semantic proximity Read ↗

Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study.Semantic proximity Read ↗

Fine mapping of a region of rat chromosome 12 close to the aspermia (as) locus and comparison with the human orthologous regions.Semantic proximity Read ↗

Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients.Semantic proximity Read ↗

Mutation analysis of three genes in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.Semantic proximity Read ↗

Implication of FKBP6 for male fertility in horses.Semantic proximity Read ↗

A Case of Male Infertility with a Reciprocal Translocation t(X;14)(p11.4;p12)Semantic proximity Read ↗

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