Article
Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.
Reproduction (Cambridge, England) - 1 Feb 2007
Zhang Wei, Zhang Sizhong, Xiao Cuiying, Yang Yuan, Zhoucun A
Abstract excerpt
Fkbp6 has been proved to be a new component of synaptonemal complexes and be involved in homologous chromosomes pairing and male infertility in mice. To explore the possible association between variations in the FKBP6 gene and impaired spermatogenesis in human, mutation screening of all the eight exons and the intron/exon boundaries of the gene was performed in 323 patients with azoospermia or severe...
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