Article
Fine mapping of a region of rat chromosome 12 close to the aspermia (as) locus and comparison with the human orthologous regions.
Experimental animals - 1 Oct 2004
Noguchi Junko, Kobayashi Eiji, Akiyama Kouyou, Kawai Yasuhiro, Ozawa Manabu, Ohnuma Katsuhiko, Kikuchi Kazuhiro, Kaneko Hiroyuki, Kunieda Tetsuo
Abstract excerpt
The aspermia mutation of the rat exhibits male sterility caused by arrest of spermatogenesis, which is controlled by an autosomal single recessive gene (as). The as locus has been mapped on rat chromosome 12. We recently identified a causative mutation for the aspermia phenotype of the as homozygous rats in the gene encoding Fkbp6, a member of the immunophilins FK506 binding proteins. In this paper, we report the...
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