Article
Induction of immune responses by attenuated isogenic mutant strains of Listeria monocytogenes.
Vaccine - 1 Jun 2003
Darji Ayub, Mohamed Walid, Domann Eugen, Chakraborty Trinad
Abstract excerpt
We have generated isogenic Listeria monocytogenes mutant strains to study the induction of protective immunity in mice. These strains harbored either a specific deletion within the actin nucleator (actA) and/or have multiple deletions within the actA and phospholipase B (plcB) genes. In comparison to the wild type parental L. monocytogenes EGDe strains, the mutant strains were extremely low in virulence and were...
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