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Article

Induction of protective CD8+ T lymphocytes by an attenuated Listeria monocytogenes actA mutant.

International immunology - 1 Dec 1992

Goossens P L, Milon G

Abstract excerpt

We tested the ability of an attenuated actA mutant of Listeria monocytogenes to induce protective immunity in mice. This mutant can enter and multiply in the cytosol of the infected host cell, but is deficient in actin-dependent cell-to-cell spread. It was found to be of attenuated virulence for inbred C3H mice: the LD50 after i.v. injection was 1000-fold higher than that of the wild-type strain. Mutant bacteria...

Topics

Animals
CD8 Antigens
Genes, Bacterial
Immunity
Listeria monocytogenes
Liver
Mice
Mice, Inbred C3H
Mutation
Spleen
T-Lymphocytes

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Identifiers

PMID: 1286064
DOI: 10.1093/intimm/4.12.1413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1286064-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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