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Article

Conditional lethality yields a new vaccine strain of Listeria monocytogenes for the induction of cell-mediated immunity.

Infection and immunity - 1 Aug 2005

Li Zhongxia, Zhao Xinyan, Higgins Darren E, Frankel Fred R

Abstract excerpt

Listeria monocytogenes is a gram-positive intracellular pathogen that can enter phagocytic and nonphagocytic cells and colonize their cytosols. Taking advantage of this property to generate an intracellular vaccine delivery vector, we previously described a mutant strain of L. monocytogenes, Deltadal Deltadat, which is unable to synthesize cell wall by virtue of deletions in two genes (dal and dat) required for...

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Identifiers

PMID: 16041022
DOI: 10.1128/IAI.73.8.5065-5073.2005
PMCID: PMC1201188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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