Article
Protective immunity induced by a LLO-deficient Listeria monocytogenes.
Microbiology and immunology - 1 Apr 2010
Yin Yuelan, Zhang Chenju, Dong Hui, Niu Zhongwei, Pan Zhiming, Huang Jinlin, Jiao Xinan
Abstract excerpt
Listeria monocytogenes is a food-borne pathogen able to cause serious disease in human and animals. Listeriolysin O (LLO), a major virulence factor secreted by this bacterium, is a vacuole-specific lysin that facilitates bacterial entrance into the host cytosol. Thus, LLO plays a key role in the translocation and intracellular spread of L. monocytogenes. To study the effect of LLO on virulence and immunopotency,...
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