Article
In vitro properties of a Listeria monocytogenes bacteriophage-resistant mutant predict its efficacy as a live oral vaccine strain.
Infection and immunity - 1 Dec 2011
Spears Patricia A, Suyemoto M Mitsu, Hamrick Terri S, Wolf Rebecca L, Havell Edward A, Orndorff Paul E
Abstract excerpt
A Listeria monocytogenes glcV mutation precludes the binding of certain listerial phages and produces a profound attenuation characterized by the absence of detectable mutants in the livers and spleens of orally inoculated mice. In vitro, we found that the mutant formed plaques on mouse enterocyte monolayers as efficiently as the parent but the plaques formed were smaller. Intracellular growth rate determinations...
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