Article
Cutting edge: protective cell-mediated immunity to Listeria monocytogenes in the absence of myeloid differentiation factor 88.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2003
Way Sing Sing, Kollmann Tobias R, Hajjar Adeline M, Wilson Christopher B
Abstract excerpt
In addition to their role in triggering innate immune responses, Toll-like receptors are proposed to play a key role in linking the innate and adaptive arms of the immune response. The majority of cellular responses downstream of Toll-like receptors are mediated through the adapter molecule myeloid differentiation factor 88 (MyD88), and mice with a targeted deletion of MyD88 are highly susceptible to bacterial...
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