Article
Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease.
Human genetics - 1 Aug 2003
Harold Denise, Peirce Timothy, Moskvina Valentina, Myers Amanda, Jones Susan, Hollingworth Paul, Moore Pamela, Lovestone Simon, Powell John, Foy Catherine, Archer Nicola, Walter Sarah, Edmonson Amanda, McIlroy Stephen, Craig David, Passmore Peter A, Goate Alison, Hardy John, O'Donovan Michael, Williams Julie, Liddell Malcolm, Owen Michael J, Jones Lesley
Abstract excerpt
There is substantial evidence for a susceptibility gene for late-onset Alzheimer's disease (AD) on chromosome 10. One of the characteristic features of AD is the degeneration and dysfunction of the cholinergic system. The genes encoding choline acetyltransferase (ChAT) and its vesicular transporter (VAChT), CHAT and SLC18A3 respectively, map to the linked region of chromosome 10 and are therefore both positional...
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