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Article

A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease.

Pharmacogenetics and genomics - 1 Feb 2006

Harold Denise, Macgregor Stuart, Patterson Cathryn E, Hollingworth Paul, Moore Pamela, Owen Michael J, Williams Julie, O'Donovan Michael, Passmore Peter, McIlroy Stephen, Jones Lesley

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a devastating neurodegeneration with a characteristic deficit in cholinergic neurotransmission. Treatment with acetylcholinesterase (AChE) inhibitors aims to reverse this deficit and does ameliorate the decline in cognition in some AD patients, although response is variable. OBJECTIVE: To examine whether sequence variation in the gene encoding choline acetyltransferase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16424819
DOI: 10.1097/01.fpc.0000189799.88596.04

Genes

CHAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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