Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study.

doi:10.1002/ajmg.b.30068

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Article

Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2005

Cook Lynnette J, Ho Luk W, Wang Lin, Terrenoire Edith, Brayne Carol, Evans John Grimley, Xuereb John, Cairns Nigel J, Turic Dragana, Hollingworth Paul, Moore Pamela J, Jehu Luke, Archer Nicola, Walter Sarah, Foy Catherine, Edmondson Amanda, Powell John, Lovestone Simon, Williams Julie, Rubinsztein David C

Abstract excerpt

Consistent deficits in the cholinergic system are evident in the brains of Alzheimer's Disease (AD) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (AChE), and choline acetyltransferase (ChAT), increased butyrylcholinesterase (BChE) activity, and a selective loss of nicotinic acetylcholine receptors (nAChRs). Accordingly, we have analyzed polymorphisms in the genes encoding...

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PMID: 15690550
DOI: 10.1002/ajmg.b.30068

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