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Homozygosity of the interleukin-10 receptor 1 G330R allele is associated with schizophrenia.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2007

Schosser Alexandra, Aschauer Harald N, Wildenauer Dieter B, Schwab Sibylle G, Albus Margot, Maier Wolfgang, Schloegelhofer Monika, Leisch Friedrich, Hornik Kurt, Murray Sarah S, Gasche Christoph

Abstract excerpt

Infections of unknown origin and an altered immune response have been hypothesized to play a role in the pathogenesis of schizophrenia. We have previously identified two single nucleotide polymorphisms (SNPs) of the IL-10 receptor 1 (IL-10R1) causing a substitution of glycine 330 to arginine (G330R) and of serine 138 to glycine (S138G). A possible association between these IL-10R1 variants and schizophrenia has...

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PMID: 17066477
DOI: 10.1002/ajmg.b.30416

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