Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD.

Frontiers in immunology - 1 Jan 2020

Werner Lael, Lee Yu Nee, Rechavi Erez, Lev Atar, Yerushalmi Baruch, Ling Galina, Shah Neil, Uhlig Holm H, Weiss Batia, Somech Raz, Snapper Scott B, Shouval Dror S

Abstract excerpt

Patients with loss-of-function mutations in IL10 or IL10 receptor (IL10R) genes develop severe, medical-refractory, infantile-onset inflammatory bowel disease (IBD). We have previously reported significant alterations in innate and adaptive immune responses in these patients. Next generation sequencing platforms enable a comprehensive assessment of T cell receptor (TCR) and B cell receptor (BCR) repertoire...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptive Immunity
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, T-Cell Receptor beta

Share to Inflammatory Bowel Diseases

Share to Interleukin-10

Share to Lymphocytes

Share to Receptors, Antigen, B-Cell

Share to Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 32117262
DOI: 10.3389/fimmu.2020.00109
PMCID: PMC7017840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD.PMID 32117262Read ↗

Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.Semantic proximity Read ↗

A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside.Semantic proximity Read ↗

Phenotypic Characterization of Very Early-Onset Inflammatory Bowel Disease with Interleukin-10 Signaling Deficiency: Based on a Large Cohort Study.Semantic proximity Read ↗

Phenotypic characterization of very early-onset IBD due to mutations in the IL10, IL10 receptor alpha or beta gene: a survey of the Genius Working Group.Semantic proximity Read ↗

The clinical, molecular, and therapeutic features of patients with IL10/IL10R deficiency: a systematic review.Semantic proximity Read ↗

Clinical and cellular phenotypes resulting from a founder mutation in IL10RB.Semantic proximity Read ↗

Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations.Semantic proximity Read ↗

Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation.Semantic proximity Read ↗

Immune Dysregulation Resulting From Impaired Interleukin-10 And The Interleukin-10 Receptor Signaling: A Systematic Review of 284 Monogenic PatientsSemantic proximity Read ↗

Clinical features of interleukin 10 receptor gene mutations in children with very early-onset inflammatory bowel disease.Semantic proximity Read ↗

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.Semantic proximity Read ↗

Molecular diagnosis of infantile onset inflammatory bowel disease by exome sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.