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Article

The IL-10R1 S138G loss-of-function allele and ulcerative colitis.

Genes and immunity - 1 Jan 2009

Grundtner P, Gruber S, Murray S S, Vermeire S, Rutgeerts P, Decker T, Lakatos P L, Gasche C

Abstract excerpt

Genetic predisposition is a risk factor for the development of inflammatory bowel diseases (IBDs). Disruption of the interleukin (IL)-10 pathway in mice causes intestinal inflammation similar to human IBD. Two common non-synonymous IL-10R1 variants, S138G and G330R, were cloned and expressed in HeLa and Ba/F3. A reduction in IL-10-induced STAT1 and STAT3 activation was seen for IL-10R1-S138G (but not...

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Source

Identifiers

PMID: 18800073
DOI: 10.1038/gene.2008.72

Genes

STAT1
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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