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Article

Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2003

Matsuki Naoto, Stanic Aleksandar K, Embers Monica E, Van Kaer Luc, Morel Laurence, Joyce Sebastian

Abstract excerpt

Nonobese diabetic (NOD) mice, a model for type I diabetes (TID), have reduced numbers of invariant V alpha 14J alpha 18 TCR alpha-chain-positive natural T (iNKT) cells that do not release IL-4 in response to in vivo activation through their Ag receptor. The deficit in iNKT cell number and function is implicated in immune dysregulation and the etiology of TID. Therefore, we reasoned that the genetic determinant(s)...

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Identifiers

PMID: 12759418
DOI: 10.4049/jimmunol.170.11.5429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice.PMID 12759418Read ↗

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