Article

Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity

2022-10-07

Abstract excerpt

The cellular prion protein PrP C mediates the neurotoxicity of prions and other protein aggregates through poorly understood mechanisms. Antibody-derived ligands against the globular domain of PrP C (GDL) can also initiate neurotoxicity by inducing an intramolecular R 208 -H 140 hydrogen bond (“H-latch”) between the α2-α3 and β2-α2 loops of PrP C . Importantly, GDL that suppress the H-latch prolong the life o...

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Literature Corpus work: e5c02f18-de3c-515d-bad2-6db1bb9c4222
DOI: 10.1101/2022.10.05.509883

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