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Article

Identifying key components of the PrPC-PrPSc replicative interface.

The Journal of biological chemistry - 5 Dec 2008

Abalos Gil C, Cruite Justin T, Bellon Anne, Hemmers Saskia, Akagi Junya, Mastrianni James A, Williamson R Anthony, Solforosi Laura

Abstract excerpt

In prion disease, direct interaction between the cellular prion protein (PrP(C)) and its misfolded disease-associated conformer PrP(Sc) is a crucial, although poorly understood step promoting the formation of nascent PrP(Sc) and prion infectivity. Recently, we hypothesized that three regions of PrP (corresponding to amino acid residues 23-33, 98-110, and 136-158) interacting specifically and robustly with...

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Identifiers

PMID: 18826953
DOI: 10.1074/jbc.M804475200
PMCID: PMC2590689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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