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Article

Dominant-negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein.

Journal of virology - 1 May 2000

Zulianello L, Kaneko K, Scott M, Erpel S, Han D, Cohen F E, Prusiner S B

Abstract excerpt

Polymorphic basic residues near the C terminus of the prion protein (PrP) in humans and sheep appear to protect against prion disease. In heterozygotes, inhibition of prion formation appears to be dominant negative and has been simulated in cultured cells persistently infected with scrapie prions. The results of nuclear magnetic resonance and mutagenesis studies indicate that specific substitutions at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10756050
DOI: 10.1128/jvi.74.9.4351-4360.2000
PMCID: PMC111952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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