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Article

The protease-sensitive N-terminal polybasic region of prion protein modulates its conversion to the pathogenic prion conformer.

The Journal of biological chemistry - 1 Nov 2021

Zhang Xiangyi, Pan Yi-Hsuan, Chen Ying, Pan Chenhua, Ma Ji, Yuan Chonggang, Yu Guohua, Ma Jiyan

Abstract excerpt

Conversion of normal prion protein (PrPC) to the pathogenic PrPSc conformer is central to prion diseases such as Creutzfeldt-Jakob disease and scrapie; however, the detailed mechanism of this conversion remains obscure. To investigate how the N-terminal polybasic region of PrP (NPR) influences the PrPC-to-PrPSc conversion, we analyzed two PrP mutants: ΔN6 (deletion of all six amino acids in NPR) and Met4-1...

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Identifiers

PMID: 34710372
DOI: 10.1016/j.jbc.2021.101344
PMCID: PMC8604679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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