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Article

Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 1997

Kaneko K, Zulianello L, Scott M, Cooper C M, Wallace A C, James T L, Cohen F E, Prusiner S B

Abstract excerpt

Studies on the transmission of human (Hu) prions to transgenic (Tg) mice suggested that another molecule provisionally designated protein X participates in the formation of nascent scrapie isoform of prion protein (PrPSc). We report the identification of the site at which protein X binds to the cellular isoform of PrP (PrPC) using scrapie-infected mouse (Mo) neuroblastoma cells transfected with chimeric Hu/MoPrP...

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Identifiers

PMID: 9294164
DOI: 10.1073/pnas.94.19.10069
PMCID: PMC23307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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