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Article

Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.

PloS one - 1 Jan 2017

Leske Henning, Hornemann Simone, Herrmann Uli Simon, Zhu Caihong, Dametto Paolo, Li Bei, Laferriere Florent, Polymenidou Magdalini, Pelczar Pawel, Reimann Regina Rose, Schwarz Petra, Rushing Elisabeth Jane, Wüthrich Kurt, Aguzzi Adriano

Abstract excerpt

Resistance to proteolytic digestion has long been considered a defining trait of prions in tissues of organisms suffering from transmissible spongiform encephalopathies. Detection of proteinase K-resistant prion protein (PrPSc) still represents the diagnostic gold standard for prion diseases in humans, sheep and cattle. However, it has become increasingly apparent that the accumulation of PrPSc does not always...

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Identifiers

PMID: 28207746
DOI: 10.1371/journal.pone.0170503
PMCID: PMC5313174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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