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Article

L-2-oxothiazolidine-4-carboxylate supplementation in murine gamma-GT deficiency.

Free radical biology & medicine - 1 Jun 2003

Held Patrice, Harding Cary O

Abstract excerpt

gamma-glutamyl transpeptidase (gamma-GT) deficiency in GGT(enu1) mice is associated with glutathionemia, glutathionuria, growth retardation, infertility, lethargy, cataracts, and shortened life span. Total liver glutathione (GSH) content is significantly reduced in gamma-GT-deficient mice due to chronic excessive GSH loss. Oral supplementation of GGT(enu1) mice with L-2-oxothiazolidine-4-carboxylate (OTZ), a...

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Identifiers

PMID: 12757858
DOI: 10.1016/s0891-5849(03)00181-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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