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Article

Ggct (γ-glutamyl cyclotransferase) plays an important role in erythrocyte antioxidant defense and red blood cell survival.

British journal of haematology - 1 Oct 2021

He Zaoke, Sun Xiaoqin, Wang Shixiang, Bai Dongsheng, Zhao Xiangyu, Han Ying, Hao Piliang, Liu Xue-Song

Abstract excerpt

The expression of GGCT (γ-glutamyl cyclotransferase) is upregulated in various human cancers. γ-glutamyl cyclotransferase enzyme activity was originally purified from human red blood cells (RBCs), but the physiological function of GGCT in RBCs is still not clear. Here we reported that Ggct deletion in mice leads to splenomegaly and progressive anaemia phenotypes, due to elevated oxidative damage and the shortened...

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PMID: 34409610
DOI: 10.1111/bjh.17775

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