Patients with genetic defects in the gamma-glutamyl cycle.

doi:10.1016/s0009-2797(97)00155-5

Back to search

Article

Patients with genetic defects in the gamma-glutamyl cycle.

Chemico-biological interactions - 24 Apr 1998

Ristoff E, Larsson A

Abstract excerpt

In the gamma-glutamyl cycle, hereditary defects have been described in four of the six enzymes namely: gamma-GC synthetase; GSH synthetase; gamma-glutamyl transpeptidase and 5-oxoprolinase. Mutants are still to be found in gamma-glutamyl cyclotransferase and in the dipeptidase. Deficiency of GSH...

Topics

Erythrocytes
Female
Glutamate-Cysteine Ligase
Glutathione
Glutathione Synthase
Humans
Male
Metabolism, Inborn Errors
Mutation
Pyroglutamate Hydrolase
gamma-Glutamyltransferase

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.