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Genetically altered mice to evaluate glutathione homeostasis in health and disease.

Free radical biology & medicine - 15 Nov 2004

Dalton Timothy P, Chen Ying, Schneider Scott N, Nebert Daniel W, Shertzer Howard G

Abstract excerpt

The tripeptide glutathione (GSH) is part of an integrated antioxidant system that protects cells and tissues from oxidative damage. Oxidative stress can result from exposure to excessive amounts of endogenous and exogenous electrophiles. Until recently, animal and cell model systems used to investigate the role of GSH in disease processes had employed chemical agents that deplete cellular GSH by inhibiting GSH...

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Identifiers

PMID: 15477003
DOI: 10.1016/j.freeradbiomed.2004.06.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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