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Article

Glutamate cysteine ligase (GCL) transgenic and gene-targeted mice for controlling glutathione synthesis.

Current protocols in toxicology - 1 Feb 2009

Mohar Isaac, Botta Dianne, White Collin C, McConnachie Lisa A, Kavanagh Terrance J

Abstract excerpt

The tripeptide glutathione (GSH) has important antioxidant properties, scavenges free radicals, and serves as a cofactor for glutathione S-transferase conjugation of many xenobiotics. GSH is synthesized in two steps. The first and, often, rate-limiting step is the formation of γ-glutamylcysteine, which is catalyzed by the inducible heterodimeric enzyme glutamate cysteine ligase (GCL). The two subunits of GCL are...

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Identifiers

PMID: 23045016
DOI: 10.1002/0471140856.tx0616s39

Genes

GCLM
GCLC

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