Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.

Experimental animals - 1 Jan 2013

Yamada Kaoru, Tsuji Takehito, Kunieda Tetsuo

Abstract excerpt

Ggt1(dwg/dwg) mice are spontaneous mutant mice with a nucleotide deletion in the Ggt1 gene. They are characterized by dwarfism, cataract, and coat color abnormality. These abnormalities in the external appearance of Ggt1(dwg/dwg) mice closely resemble those of previously reported GGT1-deficient mice, Ggt1(tm1Zuk/tm1Zuk) (Ggt1(-/-)) and Ggt1(enu1/enu1), generated by gene targeting or ENU mutagenesis. However,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Eye
Share to gamma-Glutamyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Gene Targeting

Share to Glutathione

Share to Heterozygote

Share to Mice, Mutant Strains

Source

Identifiers

PMID: 23615310
DOI: 10.1538/expanim.62.151

Genes

GGT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.PMID 23615310Read ↗

Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.Semantic proximity Read ↗

L-2-oxothiazolidine-4-carboxylate supplementation in murine gamma-GT deficiency.Semantic proximity Read ↗

gamma-Glutamyl transferase (GGT) deficiency in the GGTenu1 mouse results from a single point mutation that leads to a stop codon in the first coding exon of GGT mRNA.Semantic proximity Read ↗

Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response.Semantic proximity Read ↗

Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility.Semantic proximity Read ↗

Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation.Semantic proximity Read ↗

Knockout of SOD1 promotes conversion of selenocysteine to dehydroalanine in murine hepatic GPX1 protein.Semantic proximity Read ↗

Disruption of the Ugt1 Locus in Mice Resembles Human Crigler-Najjar Type I DiseaseSemantic proximity Read ↗

The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene.Semantic proximity Read ↗

Generation and functional characterization of mice with a disrupted glutathione S-transferase, theta 1 gene.Semantic proximity Read ↗

Essential role for Ggct in erythrocyte antioxidant defenseSemantic proximity Read ↗

Glutamate cysteine ligase (GCL) transgenic and gene-targeted mice for controlling glutathione synthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.