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Article

AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists.

Nature neuroscience - 1 Jun 2003

Hoshi Naoto, Zhang Jia-Sheng, Omaki Miho, Takeuchi Takahiro, Yokoyama Shigeru, Wanaverbecq Nicolas, Langeberg Lorene K, Yoneda Yukio, Scott John D, Brown David A, Higashida Haruhiro

Abstract excerpt

M-type (KCNQ2/3) potassium channels are suppressed by activation of G(q/11)-coupled receptors, thereby increasing neuronal excitability. We show here that rat KCNQ2 can bind directly to the multivalent A-kinase-anchoring protein AKAP150. Peptides that block AKAP150 binding to the KCNQ2 channel complex antagonize the muscarinic inhibition of the currents. A mutant form of AKAP150, AKAP(DeltaA), which is unable to...

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Identifiers

PMID: 12754513
DOI: 10.1038/nn1062
PMCID: PMC3941299

Genes

KCNQ2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists.PMID 12754513Read ↗

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