Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Jan 2011

Lin Lin, Sun Wei, Kung Faith, Dell'Acqua Mark L, Hoffman Dax A

Abstract excerpt

Kv4.2, as the primary α-subunit of rapidly inactivating, A-type voltage-gated K(+) (Kv) channels expressed in hippocampal CA1 pyramidal dendrites, plays a critical role in regulating their excitability. Activity-dependent trafficking of Kv4.2 relies on C-terminal protein kinase A (PKA) phosphorylation. A-kinase-anchoring proteins (AKAPs) target PKA to glutamate receptor and ion channel complexes to allow for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A Kinase Anchor Proteins
Share to Action Potentials

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

Share to Guanylate Kinases

Share to Hippocampus

Share to PDZ Domains

Share to Protein Transport

Share to Shal Potassium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 21273417
DOI: 10.1523/JNEUROSCI.5383-10.2011
PMCID: PMC3035425

Genes

CA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.PMID 21273417Read ↗

Regulation of postsynaptic structure and function by an A-kinase anchoring protein-membrane-associated guanylate kinase scaffolding complex.Semantic proximity Read ↗

KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.Semantic proximity Read ↗

A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits.Semantic proximity Read ↗

NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²⁺-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin.Semantic proximity Read ↗

Protein kinase a mediates activity-dependent Kv4.2 channel trafficking.Semantic proximity Read ↗

Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.Semantic proximity Read ↗

AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors.Semantic proximity Read ↗

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit.Semantic proximity Read ↗

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunitSemantic proximity Read ↗

Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors.Semantic proximity Read ↗

Differential regulation of CaV1.2 channels by cAMP-dependent protein kinase bound to A-kinase anchoring proteins 15 and 79/150.Semantic proximity Read ↗

Type I TARPs regulate Kv7.2 potassium channels and susceptibility to seizuresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.